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Short Total Synthesis of Ajoene
Author(s) -
Silva Filipa,
Khokhar Shaista S.,
Williams Danielle M.,
Saunders Robert,
Evans Gareth J. S.,
Graz Michael,
Wirth Thomas
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201808605
Subject(s) - allicin , total synthesis , polysulfide , simple (philosophy) , chemistry , biochemical engineering , organic chemistry , engineering , philosophy , electrode , epistemology , electrolyte
We describe a short total synthesis of ajoene, a major biologically active constituent of garlic. The instability of allicin as the only other known alternative starting material has led to the development of a reliable procedure for the synthesis of ajoene from simple building blocks that is also suitable for upscale operations.