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Tunable Orthogonal Reversible Covalent (TORC) Bonds: Dynamic Chemical Control over Molecular Assembly
Author(s) -
Reuther James F.,
Dahlhauser Samuel D.,
Anslyn Eric V.
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201808371
Subject(s) - covalent bond , non covalent interactions , dynamic covalent chemistry , macromolecule , chemistry , nanotechnology , self assembly , polynucleotide , combinatorial chemistry , computer science , molecule , materials science , supramolecular chemistry , hydrogen bond , organic chemistry , biochemistry
Dynamic assembly of macromolecules in biological systems is one of the fundamental processes that facilitates life. Although such assembly most commonly uses noncovalent interactions, a set of dynamic reactions involving reversible covalent bonding is actively being exploited for the design of functional materials, bottom‐up assembly, and molecular machines. This Minireview highlights recent implementations and advancements in the area of tunable orthogonal reversible covalent (TORC) bonds for these purposes, and provides an outlook for their expansion, including the development of synthetically encoded polynucleotide mimics.