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Ring‐Opening Copolymerization of Maleic Anhydride with Functional Epoxides: Poly(propylene fumarate) Analogues Capable of Post‐Polymerization Modification
Author(s) -
Chen Yusheng,
Wilson James A.,
Petersen Shan R.,
Luong Derek,
Sallam Sahar,
Mao Jialin,
Wesdemiotis Chrys,
Becker Matthew L.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201807419
Subject(s) - maleic anhydride , copolymer , polymer chemistry , polymerization , polymer , ring opening polymerization , chemistry , yield (engineering) , materials science , organic chemistry , metallurgy
Three functional epoxides were copolymerized with maleic anhydride to yield degradable poly(propylene fumarate) analogues. The polymers were modified post‐polymerization and post‐printing with either click‐type addition reactions or UV deprotection to either attach bioactive species or increase the hydrophilicity. Successful dye attachment, induced wettability, and improved cell spreading show the viability of these analogues in biomaterials applications.