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Silver‐Promoted Oxidative Benzylic C−H Trifluoromethoxylation
Author(s) -
Yang Haodong,
Wang Feng,
Jiang Xiaohuan,
Zhou Yu,
Xu Xiufang,
Tang Pingping
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201807144
Subject(s) - trifluoromethyl , reagent , chemistry , oxidative phosphorylation , medicinal chemistry , organic chemistry , alkyl , biochemistry
A silver‐promoted oxidative benzylic C−H trifluoromethoxylation has been reported for the first time. With trifluoromethyl arylsulfonate as the trifluoromethoxylation reagent, various arenes, having diverse functional groups, undergo trifluoromethoxylation of their benzylic C−H bonds to form trifluoromethyl ethers under mild reaction conditions. In addition, the trifluoromethoxylation and the fluorination of methyl groups of electron‐rich arenes have been achieved to prepare α‐fluorobenzyl trifluoromethyl ethers in one step.