(P,C) Cyclometalated Gold(III) Complexes: Highly Active Catalysts for the Hydroarylation of Alkynes | Zendy

Blons Charlie | Zendy; MalletLadeira Sonia | Zendy; Amgoune Abderrahmane | Zendy; Bourissou Didier | Zendy

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(P,C) Cyclometalated Gold(III) Complexes: Highly Active Catalysts for the Hydroarylation of Alkynes

Author(s) -

Blons Charlie,

MalletLadeira Sonia,

Amgoune Abderrahmane,

Bourissou Didier

Publication year - 2018

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201807106

Subject(s) - catalysis , intermolecular force , ligand (biochemistry) , chemistry , selectivity , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , molecule , receptor , biochemistry

The first catalytic application of well‐defined (P,C) cyclometalated gold(III) complexes is reported. The bench‐stable bis(trifluoroacetyl) complexes 2 a , b perform very well in the intermolecular hydroarylation of alkynes. The reaction is broad in scope, it proceeds within few hours at 25 °C at catalytic loadings of 0.1–5 mol %. The electron‐rich arene adds across the C≡C bond with complete regio‐ and stereo‐selectivity. The significance of well‐defined gold(III) complexes and ligand design are highlighted in a powerful but challenging catalytic transformation.

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