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Non‐Directed Cross‐Dehydrogenative (Hetero)arylation of Allylic C(sp 3 )−H bonds enabled by C−H Activation
Author(s) -
Lerchen Andreas,
Knecht Tobias,
Koy Maximilian,
Ernst Johannes B.,
Bergander Klaus,
Daniliuc Constantin G.,
Glorius Frank
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201807047
Subject(s) - allylic rearrangement , olefin fiber , derivatization , chemistry , surface modification , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , high performance liquid chromatography
Abstract Herein, we report the selective, non‐directed and cross‐dehydrogenative coupling of allylic C(sp 3 )−H bonds with C(sp 2 )−H bonds of (hetero)arenes. The methodology employs olefins and (hetero)arenes which are abundantly available chemical feedstocks, and could be applied in late‐stage functionalization reactions of pharmaceuticals. Furthermore, the system exclusively delivers the allylic C−C coupling products highlighting the preservation of the olefin substitution pattern for further derivatization.