Premium
α‐Sila‐Dipeptides: Synthesis and Characterization
Author(s) -
Minkovich Boris,
Ruderfer Ilya,
Kaushansky Alexander,
BravoZhivotovskii Dmitry,
Apeloig Yitzhak
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201807027
Subject(s) - characterization (materials science) , combinatorial chemistry , chemistry , materials science , nanotechnology
The first two α‐sila‐dipeptides, 7 and cyclo‐sila‐dipeptide 8 , were synthesized and characterized by several methods, including X‐ray crystallography. Bulky t ‐BuMe 2 Si substituents provide some kinetic stabilization to the synthesized molecules. 7 and 8 are the first examples of a “Si for C switch” in the central α‐position of an amino acid or a peptide, in which silicon is bonded to both the amino and the carbonyl groups.