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A Platinum(II) Complex of Heptamethine Cyanine for Photoenhanced Cytotoxicity and Cellular Imaging in Near‐IR Light
Author(s) -
Mitra Koushambi,
Lyons Charles E.,
Hartman Matthew C. T.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806911
Subject(s) - singlet oxygen , cyanine , cytotoxicity , photodynamic therapy , chemistry , platinum , cytotoxic t cell , cisplatin , photochemistry , quantum yield , stereochemistry , fluorescence , oxygen , in vitro , biochemistry , biology , organic chemistry , catalysis , physics , chemotherapy , quantum mechanics , genetics
Controlled generation of cytotoxic agents with near‐IR light is a current focus of photoactivated cancer therapy, including that involving cytotoxic platinum species. A heptamethine cyanine scaffolded Pt II complex, IR797‐Platin exhibits unprecedented Pt−O bond scission and enhancement in DNA platination in near‐IR light. This complex also displayed significant singlet oxygen quantum yield thereby qualifying as a near‐IR photodynamic therapeutic agent. The complex showed 30–60 fold enhancement of cytotoxicity in near‐IR light in various cancer cell lines. The cellular imaging properties were also leveraged to observe its significant co‐localization in cytoplasmic organelles. This is the first demonstration of a near‐IR light‐initiated therapy involving the cytotoxic effects of both active cisplatin and singlet oxygen.