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Selective and Catalytic Hydrocarboxylation of Enamides and Imines with CO 2 to Generate α,α‐Disubstituted α‐Amino Acids
Author(s) -
Ju Tao,
Fu Qiang,
Ye JianHeng,
Zhang Zhen,
Liao LiLi,
Yan SiShun,
Tian XingYang,
Luo ShuPing,
Li Jing,
Yu DaGang
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806874
Subject(s) - carboxylation , chemistry , catalysis , derivatization , combinatorial chemistry , selectivity , organic chemistry , amino acid , high performance liquid chromatography , biochemistry
The first catalytic hydrocarboxylation of enamides and imines with CO 2 to generate valuable α,α‐disubstituted α‐amino acids is reported. Notably, excellent chemo‐ and regio‐selectivity are achieved, significantly different from previous reports on β‐carboxylation of enamides, homocoupling or reduction of imines. Moreover, this transition‐metal‐free procedure exhibits low loading of an inexpensive catalyst, easily available substrates, mild reaction conditions, high efficiency, facile scalability and easy product derivatization, providing great potential for application in organic synthesis, pharmaceutical chemistry, and biochemistry.