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Multimodality Imaging Agents with PET as the Fundamental Pillar
Author(s) -
Ni Dalong,
Ehlerding Emily B.,
Cai Weibo
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806853
Subject(s) - multimodality , positron emission tomography , magnetic resonance imaging , preclinical imaging , medical physics , pet imaging , nanomedicine , modalities , medicine , computer science , nuclear medicine , radiology , nanotechnology , materials science , in vivo , nanoparticle , microbiology and biotechnology , biology , world wide web , social science , sociology
Positron emission tomography (PET) provides quantitative information in vivo with ultra‐high sensitivity but is limited by its relatively low spatial resolution. Therefore, PET has been combined with other imaging modalities, and commercial systems such as PET/computed tomography (CT) and PET/magnetic resonance (MR) have become available. Inspired by the emerging field of nanomedicine, many PET‐based multimodality nanoparticle imaging agents have been developed in recent years. This Minireview highlights recent progress in the design of PET‐based multimodality imaging nanoprobes with an aim to overview the major advances and key challenges in this field and substantially improve our knowledge of this fertile research area.