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HFIP‐Assisted C−H Functionalization by Cp*Co III : Access to Key Reactive Cobaltacycles and Implication in Catalysis
Author(s) -
SanjoséOrduna Jesús,
Sarria Toro Juan Manuel,
PérezTemprano Mónica H.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806847
Subject(s) - metalation , surface modification , cationic polymerization , catalysis , chemistry , diphenylacetylene , combinatorial chemistry , medicinal chemistry , photochemistry , organic chemistry
Described here is a synthetic approach to access two of the most widely invoked cationic cobaltacycles in Cp*Co III ‐catalyzed C−H functionalization reactions by C−H activation. The unique stabilizing capability of MeCN was used to surmount the previously proposed reversible nature of the C−H metalation step. Moreover, it is revealed the boosting effect of 1,1,1,3,3,3‐hexafluoroisopropanol in the metalation step and in the reaction between N ‐pyrimidinylindole and diphenylacetylene under catalytic conditions.