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Inside Back Cover: Lipase‐Catalyzed Dynamic Kinetic Resolution of C 1 ‐ and C 2 ‐Symmetric Racemic Axially Chiral 2,2′‐Dihydroxy‐1,1′‐biaryls (Angew. Chem. Int. Ed. 32/2018)
Author(s) -
Moustafa Gamal A. I.,
Oki Yasuhiro,
Akai Shuji
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806826
Subject(s) - racemization , kinetic resolution , enantioselective synthesis , lipase , chemistry , catalysis , yield (engineering) , biocatalysis , kinetic energy , axial chirality , organic chemistry , stereochemistry , reaction mechanism , enzyme , materials science , physics , quantum mechanics , metallurgy
The radical‐mediated racemization has often hampered the production of optically pure 1,1′‐bi‐2‐naphthols (BINOLs) in transition‐metal‐catalyzed enantioselective oxidative couplings of 2‐naphthols. In their Communication on page 10278 ff., S. Akai et al. effectively use this undesired racemization and establish the first lipase/RU‐integrated dynamic kinetic resolution of racemic C 1 ‐ and C 2 ‐symmetric biaryl diols to afford homochiral biaryls in up to 98% yield and up to 98% ee .