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Back Cover: A Regio‐ and Diastereoselective Anodic Aryl–Aryl Coupling in the Biomimetic Total Synthesis of (−)‐Thebaine (Angew. Chem. Int. Ed. 34/2018)
Author(s) -
Lipp Alexander,
Ferenc Dorota,
Gütz Christoph,
Geffe Mario,
Vierengel Nina,
Schollmeyer Dieter,
Schäfer Hans J.,
Waldvogel Siegfried R.,
Opatz Till
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806821
Subject(s) - thebaine , aryl , substrate (aquarium) , cover (algebra) , chemistry , coupling (piping) , stereochemistry , combinatorial chemistry , materials science , organic chemistry , engineering , alkyl , oceanography , codeine , morphine , pharmacology , geology , mechanical engineering , metallurgy , medicine
Enforcement of selectivity through a combination of electrochemistry and substrate design enabled the biomimetic synthesis of the economically important opium alkaloid (−)‐thebaine. In their Communication on page 11055 ff., T. Opatz and co‐workers present a regio‐ and diastereoselective anodic coupling of 3′,4′,5′‐trioxygenated laudanosine derivatives, thereby helping to overcome a long‐standing electrosynthetic challenge. Graphic edited by L. Großmann (Mainz).