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Iridium‐Catalyzed Reductive Alkylations of Secondary Amides
Author(s) -
Ou Wei,
Han Feng,
Hu XiuNing,
Chen Hang,
Huang PeiQiang
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806747
Subject(s) - nucleophile , chemoselectivity , iridium , catalysis , chemistry , combinatorial chemistry , scope (computer science) , surface modification , organic chemistry , computer science , programming language
Reported herein is the first direct, metal‐catalyzed reductive functionalization of secondary amides to give functionalized amines and heterocycles. The method is shown to have exceptionally broad scope with respect to suitable nucleophiles, which cover both hard and soft C nucleophiles as well as a P nucleophile. The reaction exhibits good chemoselectivity and tolerates several sensitive functional groups.