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Mechanochemical Activation of Zinc and Application to Negishi Cross‐Coupling
Author(s) -
Cao Qun,
Howard Joseph L.,
Wheatley Emilie,
Browne Duncan L.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806480
Subject(s) - negishi coupling , zinc , substrate (aquarium) , concomitant , coupling reaction , chemistry , coupling (piping) , materials science , reagent , metallurgy , organic chemistry , catalysis , mathematics , biology , ecology , statistics
A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross‐coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp 3 )–C(sp 2 ) and C(sp 2 )–C(sp 2 ) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.