Manganese‐Catalyzed Redox‐Neutral C−H Olefination of Ketones with Unactivated Alkenes | Zendy

Hu Yuanyuan | Zendy; Zhou Bingwei | Zendy; Chen Hui | Zendy; Wang Congyang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Manganese‐Catalyzed Redox‐Neutral C−H Olefination of Ketones with Unactivated Alkenes

Author(s) -

Hu Yuanyuan,

Zhou Bingwei,

Chen Hui,

Wang Congyang

Publication year - 2018

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201806287

Subject(s) - metalation , chemistry , catalysis , reactivity (psychology) , deprotonation , manganese , redox , stoichiometry , medicinal chemistry , reaction mechanism , photochemistry , organic chemistry , ion , medicine , alternative medicine , pathology

Since 1987, stoichiometric cyclomanganation of ketones and subsequent reactions with olefins in the presence of either palladium salts or trimethylamine N ‐oxide (Me 3 N + O − ) have been reported, but the catalytic versions remain untouched so far. Herein, the first manganese‐catalyzed redox‐neutral C−H olefination of ketones with unactivated alkenes is described, and shows a distinct reactivity with its parent stoichimetric reactions. Remarkably, mechanistic experiments and DFT calculations uncovers a unique concerted bis‐metalation deprotonation (CBMD) mechanism of the Mn‐Zn‐enabled C−H bond activation.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research