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Late‐Stage Peptide Diversification by Position‐Selective C−H Activation
Author(s) -
Wang Wei,
Lorion Mélanie M.,
Shah Jagrut,
Kapdi Anant R.,
Ackermann Lutz
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806250
Subject(s) - peptide , diversification (marketing strategy) , drug discovery , chemistry , combinatorial chemistry , ruthenium , catalysis , computational biology , biology , biochemistry , business , marketing
The late‐stage modification of structurally complex peptides bears great potential for drug discovery, crop protection, and the pharmaceutical industry, among others. Whereas traditional approaches largely rely on prefunctionalizations, C−H activation catalysis has in recent years emerged as an increasingly powerful tool for post‐translational peptide modifications in a step‐economic manner. Herein, we summarize recent progress in organometallic C−H activation on peptides until June 2018, including position‐ and chemoselective palladium‐, ruthenium‐, and manganese‐catalyzed processes.