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Comparing Neutral (Monometallic) and Anionic (Bimetallic) Aluminum Complexes in Hydroboration Catalysis: Influences of Lithium Cooperation and Ligand Set
Author(s) -
Pollard Victoria A.,
Fuentes M. Ángeles,
Kennedy Alan R.,
McLellan Ross,
Mulvey Robert E.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806168
Subject(s) - hydroboration , chemistry , bimetallic strip , catalysis , ligand (biochemistry) , lithium (medication) , combinatorial chemistry , alkyl , benzophenone , substrate (aquarium) , hydride , organic chemistry , polymer chemistry , metal , medicine , biochemistry , receptor , endocrinology , oceanography , geology
Bimetallic lithium aluminates and neutral aluminum counterparts are compared as catalysts in hydroboration reactions with aldehydes, ketones, imines and alkynes. Possessing Li–Al cooperativity, ate catalysts are found to be generally superior. Catalytic activity is also influenced by the ligand set, alkyl and/or amido. Devoid of an Al−H bond, i Bu 2 Al(TMP) operates as a masked hydride reducing benzophenone through a β‐Η transfer process. This catalyst library therefore provides an entry point into the future design of Al catalysts targeting substrate specific transformations.