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Back Cover: Catalyst‐Dependent Chemoselective Formal Insertion of Diazo Compounds into C−C or C−H Bonds of 1,3‐Dicarbonyl Compounds (Angew. Chem. Int. Ed. 32/2018)
Author(s) -
Liu Zhaohong,
Sivaguru Paramasivam,
Zai Giuseppe,
Anderson Edward A.,
Bi Xihe
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806124
Subject(s) - diazo , insertion reaction , chemistry , catalysis , alkylation , carbon fibers , medicinal chemistry , stereochemistry , organic chemistry , materials science , composite number , composite material
The construction of all‐carbon quaternary centers by one‐carbon insertions into C−C bonds is a formidable challenge. In their Communication on page 8927 ff. (Issue 29), X. Bi and co‐workers report on the catalyst‐dependent chemoselective insertion of diazo compounds into 1,3‐dicarbonyl species. In the presence of AgOTf, the diazo compounds selectively insert into the C(=O)−C bond, affording 1,4‐dicarbonyl products with an all‐carbon α‐quaternary center. In the presence of Sc(OTf) 3 , on the other hand, C−H insertion results in α‐C−H alkylation products.