Premium
Construction of Quaternary Stereocenters by Palladium‐Catalyzed Carbopalladation‐Initiated Cascade Reactions
Author(s) -
Ping Yuanyuan,
Li Yuxiu,
Zhu Jieping,
Kong Wangqing
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201806088
Subject(s) - stereocenter , domino , enantioselective synthesis , palladium , cascade , cascade reaction , combinatorial chemistry , stereochemistry , chemistry , catalysis , organic chemistry , chromatography
The enantioselective synthesis of molecules containing quaternary stereocenters is a field of intense research interest and development. Among the known organic transformations, carbopalladation‐initiated domino transformations constitutes a general method for the construction of compounds containing cyclic or spiro quaternary stereocenters. In this Minireview, recent achievements in palladium‐catalyzed domino Heck/C−H functionalizations and developments in enantioselective carbopalladation‐initiated domino processes are summarized.