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Chemoenzymatic Deracemization of Chiral Sulfoxides
Author(s) -
Nosek Vladimír,
Míšek Jiří
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201805858
Subject(s) - oxaziridine , enantioselective synthesis , sulfoxide , chemistry , combinatorial chemistry , organic chemistry , catalysis
The highly enantioselective enzyme methionine sulfoxide reductase A was combined with an oxaziridine‐type oxidant in a biphasic setup for the deracemization of chiral sulfoxides. Remarkably, high ee values were observed with a wide range of substrates, thus providing a practical route for the synthesis of enantiomerically pure sulfoxides.