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Mechanochemical Rhodium(III)‐ and Gold(I)‐Catalyzed C−H Bond Alkynylations of Indoles under Solventless Conditions in Mixer Mills
Author(s) -
Hermann Gary N.,
Unruh Marvin T.,
Jung SeHyeong,
Krings Maik,
Bolm Carsten
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201805778
Subject(s) - rhodium , catalysis , chemistry , bond , medicinal chemistry , polymer chemistry , organic chemistry , business , finance
Mechanochemical activations in Rh III ‐ and Au I ‐catalyzed C−H alkynylations lead selectively to C 2 ‐ and C 3 ‐alkynylated indoles. The processes show excellent functional group tolerance, do not require additional heating and proceed under solventless conditions. Compared to solvent‐based standard protocols, the reaction times are shorter and the catalyst quantities lower resulting in high product yields under ambient atmosphere in mixer mills.