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Enantioseparation of Au 20 (PP 3 ) 4 Cl 4 Clusters with Intrinsically Chiral Cores
Author(s) -
Zhu Yanfei,
Wang Hui,
Wan Kaiwei,
Guo Jun,
He Chunting,
Yu Yue,
Zhao Luyang,
Zhang Yin,
Lv Jiawei,
Shi Lin,
Jin Renxi,
Zhang Xinxiang,
Shi Xinghua,
Tang Zhiyong
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201805695
Subject(s) - enantiopure drug , enantiomer , supramolecular chemistry , phosphine , self assembly , materials science , chirality (physics) , chemistry , crystallography , combinatorial chemistry , stereochemistry , nanotechnology , organic chemistry , enantioselective synthesis , chiral symmetry breaking , physics , crystal structure , catalysis , symmetry breaking , nambu–jona lasinio model , quantum mechanics
Au 20 (PP 3 ) 4 Cl 4 (PP 3 =tris(2‐(diphenylphosphino)ethyl) phosphine), abbreviated as Au 20 , is the only Au nanocluster with an intrinsically chiral core without a chiral environment (chiral ligands or Au‐thiolate staples), making it a unique object to understand chiral evolution and explore chiral applications. Unfortunately, the synthesized Au 20 is racemic, and its enantiomers have not yet been separated. Herein, we report a supramolecular assembly strategy with α‐cyclodextrin (α‐CD) to afford enantiopure Au 20 in bulk, and an enantiomer excess ( ee ) value of as‐separated Au 20 of 97 %. As a result of its high purity, the distinctive optical activity of Au 20 , which originates from electronic transitions confined in chiral cores, is fully explored. Theoretical studies reveals that the enantioseparation results from the preferential self‐assembly of α‐CD with organic ligands on the surface of right‐handed Au 20 .