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Cover Picture: Enantioselective Hydroamidation of Enals by Trapping of a Transient Acyl Species (Angew. Chem. Int. Ed. 28/2018)
Author(s) -
Yuan Pengfei,
Chen Jiean,
Zhao Jing,
Huang Yong
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201805219
Subject(s) - enantioselective synthesis , nucleophile , hydrogen bond , chemistry , catalysis , organocatalysis , proton , combinatorial chemistry , stereochemistry , organic chemistry , molecule , physics , quantum mechanics
Asymmetric control in proton‐shuttling catalysis requires highly organized hydrogen‐bond networks, which are often disrupted by basic substrates. In their Communication on page 8503 ff., P. Yuan, J. Chen, J. Zhao, and Y. Huang demonstrate the use of azoles as transient acyl traps to secure high enantioselectivity. This strategy provides a general and enantioselective approach to diverse β‐chiral carboxylic acid derivatives from various oxygen or nitrogen nucleophiles.