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A Radical Revolution for Trifluoromethoxylation
Author(s) -
Sahoo Basudev,
Hopkinson Matthew N.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201804939
Subject(s) - scope (computer science) , nucleophile , context (archaeology) , chemistry , combinatorial chemistry , molecule , computer science , nanotechnology , organic chemistry , materials science , catalysis , biology , paleontology , programming language
The study of OCF 3 ‐substituted molecules is somewhat hampered by a lack of diverse synthetic methods to access them. By introducing a new mild and practical reaction system for accessing the . OCF 3 radical, a recent study by Liu, Ngai, and co‐workers has the potential to dramatically expand the scope of direct trifluoromethoxylation. The features of this ground‐breaking system are discussed and placed into context with other recent advances on nucleophilic trifluoromethoxylation.