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Rhodium‐Catalyzed Highly Regio‐ and Enantioselective Hydrogenation of Tetrasubstituted Allenyl Sulfones: An Efficient Access to Chiral Allylic Sulfones
Author(s) -
Long Jiao,
Shi Liyang,
Li Xiong,
Lv Hui,
Zhang Xumu
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201804891
Subject(s) - allylic rearrangement , enantioselective synthesis , catalysis , yield (engineering) , rhodium , chemistry , combinatorial chemistry , organic chemistry , materials science , metallurgy
A highly regio‐ and enantioselective hydrogenation of challenging tetrasubstituted allenyl sulfones has been developed, affording chiral allylic sulfones in good yields with excellent regio‐ and enantioselectivities (up to 99 % yield and 99 % ee). This method provides an efficient and concise route to chiral allylic sulfones, thus offering an atom‐economic process with a wide range of potential applications in organic synthesis and medicinal chemistry.