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Selection of Anti‐gluten DNA Aptamers in a Deep Eutectic Solvent
Author(s) -
Svigelj Rossella,
Dossi Nicolò,
Toniolo Rosanna,
MirandaCastro Rebeca,
delosSantosÁlvarez Noemí,
LoboCastañón M. Jesús
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201804860
Subject(s) - aptamer , eutectic system , gluten , deep eutectic solvent , selection (genetic algorithm) , dna , nanotechnology , chemistry , computational biology , computer science , materials science , biology , artificial intelligence , food science , biochemistry , microbiology and biotechnology , organic chemistry , alloy
Herein, we show the feasibility of using deep eutectic solvents as a faster way of selecting aptamers targeting poorly water‐soluble species. This unexplored concept is illustrated for gluten proteins. In this way, aptamer‐based gluten detection can be performed directly in the extraction media with improved detectability. We envision deep implications for applications not only in food safety control but also in biomedicine.