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BODIPY Peptide Labeling by Late‐Stage C(sp 3 )−H Activation
Author(s) -
Wang Wei,
Lorion Mélanie M.,
Martinazzoli Oscar,
Ackermann Lutz
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201804654
Subject(s) - bodipy , racemization , peptide , chemistry , combinatorial chemistry , stereochemistry , fluorescence , palladium , biochemistry , catalysis , physics , quantum mechanics
Late‐stage BODIPY diversification of structurally complex amino acids and peptides was accomplished by racemization‐free palladium‐catalyzed C(sp 3 )−H activation. Transformative fluorescence modification proved viable by triazole‐assisted C(sp 3 )−H arylation in a chemo‐ and site‐selective fashion, providing modular access to novel BODIPY peptide sensors.