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Inside Back Cover: Optogenetic Control of Voltage‐Gated Calcium Channels (Angew. Chem. Int. Ed. 24/2018)
Author(s) -
Ma Guolin,
Liu Jindou,
Ke Yuepeng,
Liu Xin,
Li Minyong,
Wang Fen,
Han Gang,
Huang Yun,
Wang Youjun,
Zhou Yubin
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201804536
Subject(s) - optogenetics , voltage dependent calcium channel , cover (algebra) , neuroscience , calcium channel , calcium , chemistry , biophysics , biology , engineering , mechanical engineering , organic chemistry
Voltage‐gated calcium channels (VGCCs) are important therapeutic targets for cardiovascular and neuropsychiatric disorders. In their Communication on page 7019 ff., Y. Zhou, Y. Wang et al. report the engineering of a novel class of genetically encoded photoswitchable inhibitors of VGCCs to control Ca 2+ signals and biological activity in excitable cells. Such an optogenetic device could potentially be adapted to suppress cardiac arrhythmia through the application of light.