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BSA‐IrO 2 : Catalase‐like Nanoparticles with High Photothermal Conversion Efficiency and a High X‐ray Absorption Coefficient for Anti‐inflammation and Antitumor Theranostics
Author(s) -
Zhen Wenyao,
Liu Yang,
Lin Lin,
Bai Jing,
Jia Xiaodan,
Tian Huayu,
Jiang Xiue
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201804466
Subject(s) - photothermal therapy , nanoparticle , bovine serum albumin , nanomaterials , materials science , absorption (acoustics) , nanotechnology , chemistry , chromatography , composite material
Intrinsically integrating precise diagnosis, effective therapy, and self‐anti‐inflammatory action into a single nanoparticle is attractive for tumor treatment and future clinical application, but still remains a great challenge. In this study, bovine serum albumin–iridium oxide nanoparticles (BSA‐IrO 2 NPs) with extraordinary photothermal conversion efficiency, good photocatalytic activity, and a high X‐ray absorption coefficient were prepared through one‐step biomineralization. The nanoparticles allow tumor phototherapy and simultaneous photoacoustic/thermal imaging and computed tomography. More importantly, BSA‐IrO 2 NPs can also act as a catalase to protect normal cells against H 2 O 2 ‐induced reactive oxygen pressure and inflammation while significantly enhancing photoacoustic imaging through microbubble‐based inertial cavitation. These remarkable features may open up the exploration iridium‐based nanomaterials in theranostics.