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Diverse meta ‐C−H Functionalization of Arenes across Different Linker Lengths
Author(s) -
Jayarajan Ramasamy,
Das Jayabrata,
Bag Sukdev,
Chowdhury Rajdip,
Maiti Debabrata
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201804043
Subject(s) - surface modification , linker , cyanation , heteroatom , selectivity , chemistry , alkyl , alkylation , pyrimidine , combinatorial chemistry , palladium , catalysis , organic chemistry , stereochemistry , computer science , operating system
Arenes containing conformationally flexible long alkyl chains have been successfully functionalized at the meta ‐position. Good to excellent meta selectivity is achieved for systems with up to 20 atoms between the target C−H bond and the coordinating heteroatom of the directing group. The palladium‐catalyzed functionalization reactions include alkylation, cyanation, olefination, and acetoxylation. The meta selectivity is exclusively governed by the design of flexible pyrimidine‐based scaffolds.