Premium
Indanol‐Based Chiral Organoiodine Catalysts for Enantioselective Hydrative Dearomatization
Author(s) -
Hashimoto Takuya,
Shimazaki Yuto,
Omatsu Yamato,
Maruoka Keiji
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201803889
Subject(s) - catalysis , enantioselective synthesis , modularity (biology) , combinatorial chemistry , chemistry , organic chemistry , nanotechnology , materials science , biology , genetics
Rapid development in the last decade has rendered chiral organoiodine(I/III) catalysis a reliable methodology in asymmetric catalysis. However, due to the severely limited numbers of effective organoiodine catalysts, many reactions still give low to modest enantioselectivity. We report herein a solution to this issue through the introduction of a pivotal indanol scaffold to the catalyst design. Our catalyst architecture exhibits the advantage of high modularity and thereby expedites catalyst optimization. The catalyst was optimized for the challenging and highly sought‐after hydrative dearomatization of 2‐substituted phenols at the 4‐position.