Premium
Confined Nanopipette Sensing: From Single Molecules, Single Nanoparticles, to Single Cells
Author(s) -
Yu RuJia,
Ying YiLun,
Gao Rui,
Long YiTao
Publication year - 2019
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201803229
Subject(s) - nanotechnology , characterization (materials science) , nanoscopic scale , population , materials science , fabrication , nanoparticle , demography , sociology , medicine , alternative medicine , pathology
Nanopipettes provide a promising confined space that enables advances in electrochemical, optical, and mass spectrometric measurements at the nanoscale. They have been employed to reveal the hidden population properties and dynamics of single molecules and single particles. Moreover, new detection mechanisms based on nanopipettes have led to detailed information on single cells at high spatial and temporal resolution. In this Minireview, we focus on the fabrication and characterization of nanopipettes, summarize their wide applications for the analysis of single entities, and conclude with an outlook for advanced practical sensing.