Premium
Palladium‐Catalyzed Asymmetric C(sp 3 )−H Allylation of 2‐Alkylpyridines
Author(s) -
Murakami Ryo,
Sano Kentaro,
Iwai Tomohiro,
Taniguchi Tohru,
Monde Kenji,
Sawamura Masaya
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201802821
Subject(s) - palladium , catalysis , chemistry , physics , organic chemistry
The palladium‐catalyzed asymmetric side‐chain C(α)‐allylation of 2‐alkylpyridines, without using an external base, was developed. The high linear selectivities and enantioselectivities were achieved using new chiral diamidophosphite monodentate ligands. Given that the reaction conditions do not require an external base, this catalyst system enabled chemoselective C(α)‐allylation of 2‐alkylpyridines containing α‐carbonyl C−H bonds, which are more acidic than α‐pyridyl C−H bonds.