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Single‐Particle Reconstruction of Biological Molecules—Story in a Sample (Nobel Lecture)
Author(s) -
Frank Joachim
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201802770
Subject(s) - particle (ecology) , cryo electron microscopy , single particle analysis , resolution (logic) , sample (material) , nanotechnology , molecule , physics , chemistry , biophysics , materials science , biology , computer science , artificial intelligence , chromatography , ecology , aerosol , meteorology , quantum mechanics
Pictures tell a thousand words : The development of single‐particle cryo‐electron microscopy set the stage for high‐resolution structure determination of biological molecules. In his Nobel lecture, J. Frank describes the ground‐breaking discoveries that have enabled the development of cryo‐EM. The method has taken biochemistry into a new era.