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A Desulfurative Strategy for the Generation of Alkyl Radicals Enabled by Visible‐Light Photoredox Catalysis
Author(s) -
Xue Fei,
Wang Falu,
Liu Jiazhen,
Di Jiamei,
Liao Qi,
Lu Huifang,
Zhu Min,
He Liping,
He Huan,
Zhang Dan,
Song Hao,
Liu XiaoYu,
Qin Yong
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201802710
Subject(s) - photoredox catalysis , radical , alkyl , photochemistry , chemistry , catalysis , visible spectrum , conjugate , substrate (aquarium) , combinatorial chemistry , organic chemistry , photocatalysis , materials science , biology , mathematical analysis , mathematics , optoelectronics , ecology
Herein, we present a new desulfurative method for generating primary, secondary, and tertiary alkyl radicals through visible‐light photoredox catalysis. A process that involves the generation of N‐centered radicals from sulfinamide intermediates, followed by subsequent fragmentation, is critical to forming the corresponding alkyl radical species. This strategy has been successfully applied to conjugate addition reactions that features mild reaction conditions, broad substrate scope (>60 examples), and good functional‐group tolerance.