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Blood‐Catalyzed RAFT Polymerization
Author(s) -
Reyhani Amin,
Nothling Mitchell D.,
RanjiBurachaloo Hadi,
McKenzie Thomas G.,
Fu Qiang,
Tan Shereen,
Bryant Gary,
Qiao Greg G.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201802544
Subject(s) - raft , chain transfer , polymerization , reagent , reversible addition−fragmentation chain transfer polymerization , macromolecule , chemistry , catalysis , hydrogen peroxide , ex vivo , fragmentation (computing) , combinatorial chemistry , radical polymerization , polymer chemistry , organic chemistry , biochemistry , in vitro , biology , polymer , ecology
Abstract The use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via a reversible addition‐fragmentation chain transfer (RAFT) process is reported for the first time. No pre‐treatment of the Hb or cells was required prior to their use as polymerization catalysts, indicating the potential for synthetic engineering in complex biological microenvironments without the need for ex vivo techniques. Owing to the naturally occurring prevalence of the reagents employed in the catalytic system (Hb and hydrogen peroxide), this approach may facilitate the development of new strategies for in vivo cell engineering with synthetic macromolecules.