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Inside Cover: Directed Evolution: Bringing New Chemistry to Life (Angew. Chem. Int. Ed. 16/2018)
Author(s) -
Arnold Frances H.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201802332
Subject(s) - alkene , chemistry , nitrene , amination , cyclopropene , directed evolution , cyclopropanation , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , biochemistry , mutant , gene
New‐to‐nature chemistry has been found in natural and engineered proteins. In her Essay on page 4143 ff., F. H. Arnold explains how heme proteins have been evolved in the laboratory to catalyze a number of abiological carbine‐ and nitrene‐transfer reactions, including alkene cyclopropanation, C−H amination, and anti‐Markovnikov alkene oxidation. Fully genetically encoded engineered heme proteins also catalyze carbine insertion reactions to make C−B and C−Si bonds inside of living cells, adding completely new bonds to nature's synthetic repertoire. Picture credit: Jennifer Kan.