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Palladium‐Catalyzed para ‐Selective Alkylation of Electron‐Deficient Arenes
Author(s) -
Jiao Zhiwei,
Lim Li Hui,
Hirao Hajime,
Zhou Jianrong Steve
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201801967
Subject(s) - alkylation , chemistry , palladium , catalysis , alkyl , selectivity , nucleophile , halide , electron , medicinal chemistry , organic chemistry , photochemistry , physics , quantum mechanics
Abstract Intermolecular alkylations of electron‐deficient arenes proceed with good para selectivity. Palladium catalysts were used to generate nucleophilic alkyl radicals from alkyl halides, which then directly add onto the arenes. The arene scope and the site of alkylation are opposite to those of classical Friedel–Crafts alkylations, which prefer electron‐rich systems.