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Highly Stereoselective Synthesis of 1,3‐Dienes through an Aryl to Vinyl 1,4‐Palladium Migration/Heck Sequence
Author(s) -
Hu TianJiao,
Li MengYao,
Zhao Qian,
Feng ChenGuo,
Lin GuoQiang
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201801963
Subject(s) - stereoselectivity , palladium , aryl , heck reaction , sequence (biology) , chemistry , organic chemistry , catalysis , biochemistry , alkyl
An efficient aryl to vinyl 1,4‐palladium migration/Heck sequence was developed for the stereoselective synthesis of 1,3‐dienes. High stereoselectivity was observed not only for 1,3‐dienes bearing two similar aryl groups at terminal positions, but also for those with configurations shown to be unfavorable with previous methods.