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A Cell‐Targeted Non‐Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium‐Containing Cationic Radical Initiator
Author(s) -
Uchiyama Seiichi,
Tsuji Toshikazu,
Kawamoto Kyoko,
Okano Kentaro,
Fukatsu Eiko,
Noro Takahiro,
Ikado Kumiko,
Yamada Sayuri,
Shibata Yuka,
Hayashi Teruyuki,
Inada Noriko,
Kato Masaru,
Koizumi Hideki,
Tokuyama Hidetoshi
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201801495
Subject(s) - cationic polymerization , nanogel , fluorescence , thermometer , chemistry , incubation , polymer chemistry , photochemistry , biophysics , cytotoxicity , materials science , in vitro , organic chemistry , biochemistry , biology , drug delivery , physics , quantum mechanics
A cationic fluorescent nanogel thermometer based on thermo‐responsive N‐isopropylacrylamide and environment‐sensitive benzothiadiazole was developed with a new azo compound bearing imidazolium rings as the first cationic radical initiator. This cationic fluorescent nanogel thermometer showed an excellent ability to enter live mammalian cells in a short incubation period (10 min), a high sensitivity to temperature variations in live cells (temperature resolution of 0.02–0.84 °C in the range 20–40 °C), and remarkable non‐cytotoxicity, which permitted ordinary cell proliferation and even differentiation of primary cultured cells.