Premium
The Cooperative Effect of Both Molecular and Supramolecular Chirality on Cell Adhesion
Author(s) -
Liu Jinying,
Yuan Feng,
Ma Xiaoyu,
Auphedeous Dangi Y.,
Zhao Changli,
Liu Chuntai,
Shen Changyu,
Feng Chuanliang
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201801462
Subject(s) - nanofiber , chirality (physics) , molecule , supramolecular chemistry , adhesion , cell adhesion , phenylalanine , stereochemistry , biophysics , chemistry , materials science , nanotechnology , amino acid , biochemistry , chiral symmetry , organic chemistry , physics , biology , quantum mechanics , nambu–jona lasinio model , quark
Although helical nanofibrous structures have great influence on cell adhesion, the role played by chiral molecules in these structures on cells behavior has usually been ignored. The chirality of helical nanofibers is inverted by the odd–even effect of methylene units from homochiral l ‐phenylalanine derivative during assembly. An increase in cell adhesion on left‐handed nanofibers and weak influence of cell behaviors on right‐handed nanofibers are observed, even though both were derived from l ‐phenylalanine derivatives. Weak and negative influences on cell behavior was also observed for left‐ and right‐handed nanofibers derived from d ‐phenylalanine, respectively. The effect on cell adhesion of single chiral molecules and helical nanofibers may be mutually offset.