Premium
Supramolecular Reassembly of Self‐Exfoliated Ionic Covalent Organic Nanosheets for Label‐Free Detection of Double‐Stranded DNA
Author(s) -
Mal Arindam,
Mishra Rakesh K.,
Praveen Vakayil K.,
Khayum M. Abdul,
Banerjee Rahul,
Ajayaghosh Ayyappanpillai
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201801352
Subject(s) - ethidium bromide , covalent bond , ionic bonding , supramolecular chemistry , nanomaterials , chemistry , fluorescence , dna , ionic liquid , self assembly , aqueous solution , nanotechnology , materials science , organic chemistry , molecule , biochemistry , ion , catalysis , physics , quantum mechanics
Ionic covalent organic nanosheets (iCONs), a member of the two‐dimensional (2D) nanomaterials family, offer a unique functional platform for a wide range of applications. Herein, we explore the potential of an ethidium bromide (EB)‐based covalent organic framework ( EB‐TFP ) that self‐exfoliates in water resulting in 2D ionic covalent organic nanosheets ( EB‐TFP‐iCONs ) for the selective detection of double‐stranded DNA (dsDNA). In an aqueous medium, the self‐exfoliated EB‐TFP‐iCONs reassemble in the presence of dsDNA resulting in hybrid EB‐TFP‐iCONs‐DNA crystalline nanosheets with enhanced fluorescence at 600 nm. Detailed steady‐state and time‐resolved emission studies revealed that the reassembly phenomenon was highly selective for dsDNA when compared to single‐stranded DNA (ssDNA), which allowed us to use the EB‐TFP‐iCONs as a 2D fluorescent platform for the label‐free detection of complementary DNA strands.