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Dissipative Synthetic DNA‐Based Receptors for the Transient Loading and Release of Molecular Cargo
Author(s) -
Del Grosso Erica,
Amodio Alessia,
Ragazzon Giulio,
Prins Leonard J.,
Ricci Francesco
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201801318
Subject(s) - dissipative system , supramolecular chemistry , kinetic control , dna , chemistry , chemical reaction , selectivity , chemical process , biological system , chemical energy , kinetic energy , transient (computer programming) , nanotechnology , chemical physics , molecule , materials science , combinatorial chemistry , chemical engineering , computer science , thermodynamics , physics , organic chemistry , biology , catalysis , engineering , biochemistry , quantum mechanics , operating system
Supramolecular chemistry is moving into a direction in which the composition of a chemical equilibrium is no longer determined by thermodynamics but by the efficiency with which kinetic states can be populated by energy consuming processes. Herein, we show that DNA is ideally suited for programming chemically fueled dissipative self‐assembly processes. Advantages of the DNA‐based systems presented in this study include a perfect control over the activation site for the chemical fuel in terms of selectivity and affinity, highly selective fuel consumption that occurs exclusively in the activated complex, and a high tolerance for the presence of waste products. Finally, it is shown that chemical fuels can be used to selectively activate different functions in a system of higher complexity embedded with multiple response pathways.