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Copper‐Catalyzed Heteroarylboration of 1,3‐Dienes with 3‐Bromopyridines: A cine Substitution
Author(s) -
Smith Kevin B.,
Huang Yuan,
Brown M. Kevin
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201801139
Subject(s) - substitution (logic) , catalysis , copper , chemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , computer science , programming language
A method for the heteroarylboration of 1,3‐dienes is presented. The process involves an unusual cine substitution of 3‐bromopyridine derivatives to deliver highly functionalized heterocyclic products. Mechanistic studies are included that clarify the details of this unusual process.