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Insights into the Crystallization and Structural Evolution of Glycine Dihydrate by In Situ Solid‐State NMR Spectroscopy
Author(s) -
Cerreia Vioglio Paolo,
Mollica Giulia,
Juramy Marie,
Hughes Colan E.,
Williams P. Andrew,
Ziarelli Fabio,
Viel Stéphane,
Thureau Pierre,
Harris Kenneth D. M.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201801114
Subject(s) - glycine , in situ , crystallization , solid state nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , chemistry , phase (matter) , spectroscopy , crystallography , aqueous solution , materials science , stereochemistry , organic chemistry , nuclear magnetic resonance , amino acid , biochemistry , physics , quantum mechanics
In situ solid‐state NMR spectroscopy is exploited to monitor the structural evolution of a glycine/water glass phase formed on flash cooling an aqueous solution of glycine, with a range of modern solid‐state NMR methods applied to elucidate structural properties of the solid phases present. The glycine/water glass is shown to crystallize into an intermediate phase, which then transforms to the β polymorph of glycine. Our in situ NMR results fully corroborate the identity of the intermediate crystalline phase as glycine dihydrate, which was first proposed only very recently.