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Manganese‐Catalyzed Carbonylative Annulations for Redox‐Neutral Late‐Stage Diversification
Author(s) -
Liang YuFeng,
Steinbock Ralf,
Münch Annika,
Stalke Dietmar,
Ackermann Lutz
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201801111
Subject(s) - catalysis , manganese , redox , chemistry , combinatorial chemistry , carbonylation , organic chemistry , carbon monoxide
An inexpensive, nontoxic manganese catalyst enabled unprecedented redox‐neutral carbonylative annulations under ambient pressure. The manganese catalyst outperformed all other typically used base and precious‐metal catalysts. The outstanding versatility of the manganese catalysis manifold was reflected by ample substrate scope, setting the stage for effective late‐stage manipulations under racemization‐free conditions of a wealth of marketed drugs and natural products, including alkaloids, amino acids, steroids, and carbohydrates.