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Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N ‐(Pentafluorobenzoyloxy)carbamates
Author(s) -
Hazelden Ian R.,
Carmona Rafaela C.,
Langer Thomas,
Pringle Paul G.,
Bower John F.
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201801109
Subject(s) - chemistry , heck reaction , ligand (biochemistry) , carbamate , combinatorial chemistry , stereochemistry , organic chemistry , palladium , catalysis , receptor , biochemistry
Ligand‐enabled aza‐Heck cyclizations and cascades of N ‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐ exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.