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Calcium Fluoride Nanocrystals: Tracers for In Vivo 19 F Magnetic Resonance Imaging
Author(s) -
Ashur Idan,
AlloucheAr Hyla,
BarShir Am
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201800838
Subject(s) - homonuclear molecule , materials science , nanocrystal , ionic bonding , colloid , gadolinium , nuclear magnetic resonance , chemistry , nanotechnology , molecule , ion , organic chemistry , physics , metallurgy
Inorganic nanocrystals (NCs) have been extensively developed for a variety of uses. The ability to obtain high‐resolution NMR signals from the core nuclei of NCs in solution could offer new opportunities in materials sciences and MR imaging. Herein, we demonstrate that small, water‐soluble 19 F‐ionic NCs can average out homonuclear dipolar interactions, enabling one to obtain high‐resolution 19 F NMR signals in solution that reflect the MR properties of F − in the crystal core. Decorating 19 F‐NC surfaces with a biocompatible poly(ethylene glycol) coating maintains colloidal stability in water while preserving the NC high‐resolution 19 F NMR properties, even after further functionalization. The high content and magnetic equivalence of the fluorides within the NCs enable their use as imaging tracers for in vivo 19 F MRI by facilitating a “hot‐spot” display of their distribution.