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Human Enzymes for Organic Synthesis
Author(s) -
Winkler Margit,
Geier Martina,
Hanlon Steven P.,
Nidetzky Bernd,
Glieder Anton
Publication year - 2018
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201800678
Subject(s) - enzyme , xenobiotic , organic synthesis , chemistry , drug metabolism , biochemistry , catalysis , combinatorial chemistry
Human enzymes have been widely studied in various disciplines. The number of reactions taking place in the human body is vast, and so is the number of potential catalysts for synthesis. Herein, we focus on the application of human enzymes that catalyze chemical reactions in course of the metabolism of drugs and xenobiotics. Some of these reactions have been explored on the preparative scale. The major field of application of human enzymes is currently drug development, where they are applied for the synthesis of drug metabolites.